ABSTRACT
Abnormal deposit of β-amyloid (Aβ) is closely related with the genesis and development of Alzheimer's disease (AD). Based on Aβ for target, looking for potential therapeutic agents in the treatment of AD is a hotspot of current research. Chinese materia medica (CMM) has small toxic side effect, with multi-target, multi-channel, and multi-link effect of functions and characteristics. According to vast information from literatures in the last decade, the composition of CMM can reduce Aβ production, promote Aβ clearance, and antagonize its toxicity, thus easing the development of AD. This article summarizes and reviews the research progress on Aβ targeting CMM, in hopes of providing a reference for further study in the future prevention of AD.
ABSTRACT
The pharmacological mechaisms of Panax notoginseng saponins on nervous system diseases (Alzheimer's disease, Parkinson's disease, ischermic cerebral apoplexy and depressive disorder) , including panax notoginseng saponins, protoparaxotriol saponins, panasadiol saponins, ginsenoside Rg1, ginsenoside Rb1, ginsenoside Re and notoginsenoside R1 were summarized to analyze the study hotspots and potential advantages (such as estrogen-like effect) of notoginsenoside's pharmacological actions, provide reference for further pharmacological studies and new ideas for clinical treatment of nervous system diseases and drug studies and development.